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KMID : 1197720220150030264
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대한파킨슨병 및 이상운동질환 학회지
2022 Volume.15 No. 3 p.264 ~ p.268
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Sensitivity of Detecting Alpha-Synuclein Accumulation in the Gastrointestinal Tract and Tissue Volume Examined
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Shin Chae-Won
Kim Seong-Ik
Park Sung-Hye
Shin Jung-Hwan
Lee Chan-Young
Yang Han-Kwang
Lee Hyuk-Joon
Kong Seong-Ho
Suh Yun-Suhk
Kim Han-Joon
Jeon Beom-Seok
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Abstract
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Objective: This study aimed to evaluate whether a larger tissue volume increases the sensitivity of detecting alpha-synuclein (AS) pathology in the gastrointestinal (GI) tract.
Methods: Nine patients with Parkinson’s disease (PD) or idiopathic rapid eye movement sleep disorder (iRBD) who underwent GI operation and had full-depth intestinal blocks were included. All patients were selected from our previous study population. A total of 10 slides (5 serial sections from the proximal and distal blocks) per patient were analyzed.
Results: In previous studies, pathologic evaluation revealed phosphorylated AS (+) in 5/9 patients (55.6%) and in 1/5 controls (20.0%); in this extensive examination, this increased to 8/9 patients (88.9%) but remained the same in controls (20.0%). The severity and distribution of positive findings were similar between patients with iRBD and PD.
Conclusion: Examining a large tissue volume increased the sensitivity of detecting AS accumulation in the GI tract.
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KEYWORD
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Alpha-synuclein, Synucleinopathy, Gastrointestinal tract, Immunohistochemistry, Volume
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